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Psychedelic Definition, Meaning & Synonyms The inverse agonist clozapine caused receptor internalization independent of PKC activation. Because 5-HT2A receptor internalization can be induced by PKC activation in the absence of ligand, the investigators hypothesized that the PKC-phosphorylation–deficient 5-HT2A–S291A mutant would be insensitive to PMA-induced internalization. Consistent with their hypothesis, no internalization could be detected after PKC activation by 4 nM PMA. In addition, they also noted that the increased H-reflex amplitude was positively correlated with serotonin immunoreactivity around the motoneurons involved in the reflex. DOI had previously been shown by Miller et al. to restore excitability of extensor motoneurons that is abolished after acute spinalization in the cat. In addition, no serotonergic innervation of the lumbar-sacral spinal cord remains after a CT (Lee et al., 2005), because completely transected animals showed no 5-HT immunoreactivity at